Welcome to the Nachmani lab

Differentiation and the acquisition of cell identity are fundamental processes in multicellular organisms. In the Nachmani lab, we explore translation as a determinant of cell identity. Our research focuses on (but not limited to) ribosomal RNA modifications as key regulators of ribosome function and drivers of cell-type-specific translation, essential for establishing identity. We study ribosomal dynamics, and how cell-type-specific translation contributes to cellular function in physiological and pathological contexts, including normal hematopoiesis, leukemia, drug sensitivity and viral infection.

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​​​We utilize state-of-the-art molecular and genomic technologies, including ribosome profiling, diverse RNA modification sequencing techniques, whole-genome functional genetic screens and more. These approaches are combined with ex-vivo stem cell systems and in-vivo disease models as bone marrow transplantation, genetic models and leukemia xenografts. Using this combination we connect new molecular insights with functional outcomes to reveal their therapeutic potential for human disease.

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For more details about (some) of our on-going projects check “Research“.