Welcome to the Nachmani lab
Our Science
Acquisition of cell identity is a fundamental process in multicellular organisms. While DNA- and RNA-based mechanisms for cell identity are well established, the role of translation is yet to be defined. In the Nachmani lab, we explore translation as a determinant of cell identity.
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Our research focuses on (but is not limited to) ribosomal RNA modifications as key regulators of cell-type-specific translation. We study dynamics of ribosomal RNA modifications and of translation, and how these dynamics contribute to cellular identity and function in physiological and pathological contexts, spanning normal hematopoiesis, leukemia, drug response, and viral infection.​
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​​​​To address these questions, we employ state-of-the-art molecular and genomic technologies, including ribosome profiling, diverse RNA modification sequencing approaches, and whole-genome functional genetic screens. We combine these approaches with ex-vivo stem cell systems and in-vivo disease models as bone marrow transplantation, genetic models and leukemia xenografts. By using this combination we connect new molecular insights with functional outcomes to reveal their therapeutic potential for human disease.
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For more details about (some) of our on-going projects check “Research“.
We are always looking for talented and highly motivated researchers to join us.
To apply email a statement of research interest and CV to:
