Welcome to the Nachmani lab

Acquisition of cell identity is a fundamental process in multicellular organisms. In the Nachmani lab, we explore translation as a determinant of cell identity. Our research focuses on (but is not limited to) ribosomal RNA modifications as key regulators of ribosome function and drivers of cell-type-specific translation. We study dynamics of ribosomal RNA modifications and of translation, and how these contribute to cellular identity and function in physiological and pathological contexts. Our work spans normal hematopoiesis as well as disease settings including leukemia, drug response, and viral infection.​

​​​To address these questions, we employ state-of-the-art molecular and genomic technologies, including ribosome profiling, diverse RNA modification sequencing approaches, and whole-genome functional genetic screens. We combine these approaches with ex-vivo stem cell systems and in-vivo disease models as bone marrow transplantation, genetic models and leukemia xenografts. Using this combination we connect new molecular insights with functional outcomes to reveal their therapeutic potential for human disease.

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For more details about (some) of our on-going projects check “Research“.